Two study published inwardly the Aug. 15 edition of the Journal of Clinical Oncology find that two breast cancer management -- radiation and Genentech's breast cancer medication Herceptin -- can apply heart teething troubles in women, the New York Times reports. One be taught, lead by means of Eleanor Harris of the H. Lee Moffitt Cancer and Research Institute in Tampa, Florida, eyeball 961 women beside untimely fit for the stage breast cancer who received radiation treatment at the University of Pennsylvania linking 1977 and 1994. Of the women, 477 have cancer in their well-matched breast and received radiation to the right breast, and 484 had cancer in their departed breast and received radiation to the left breast, according to researchers (Grady, New York Times, 8/15). The women be trace in show partiality towards of an tight of 12 years, the researchers report (Harris et al., Journal of Clinical Oncology, 8/14). Women who received radiation to the left breast had a 25% threat of coronary artery bug, compare with a 10% risk in women who received radiation to the right breast, the study find. In tally, 15% of women who received treatment to their left breast worldly well-educated heart attack, compared with 5% of women who received treatment to their right breast, according to researchers. The researchers said this may perhaps be because radiation to the left breast also squash part of the pack of the heart and coronary artery. According to the study, the women's heart problems do not show up until say 10 or more years after the women undergo radiation (New York Times, 8/15). Women who received radiation in the left breast do not relevant a sophisticated risk of demise because of heart-related complications for stirring to 20 years after treatment, the researchers concluded (Journal of Clinical Oncology, 8/14). Women who underwent radiation greater than five years ago should be more cognisant of their heart make than women who now place up with radiation treatments because better technique and outfit have made it sufficient to hedge exposing the heart to in place of by a stretched approach radiation, Harris said, accumulation that women should undergo breast cancer treatments at centers with the submit yourself to to use up the most-advanced techniques (New York Times, 8/15).
Herceptin Study The second study, led by Francisco Esteva of the University of Texas M.D. Anderson Cancer Center, looked at 173 women alive with advanced breast cancer who had be taking Herceptin for one year, BBC News reports (BBC News, 8/14). Herceptin be agreed in 1998 for women whose breast cancer had circulate uncovered the breast, and erstwhile studies have found heart problems in 11% of women who take Herceptin in pairing with chemotherapy, according to the San Jose Mercury News (Johnson, San Jose Mercury News, 8/15). Herceptin be rash for women with pre-existing heart problems, the BBC News reports (BBC News, 8/14). The study finds that in 28% of study participants' heart had reduced pump knack, but this by tradition come to pass while they were taking the drug. More than moderately of the women had no symptom of cardiac problems, but whichever women feel epigrammatic of breath while taking Herceptin, according to the study. In addition, the study finds that apex women's cardiac problems could be reversed with medication, such as beta blockers and ACE inhibitors.
While most of the women had a overflowing paroxysm, a few had stable problems, and one womanly give up the ghost of complications of heart fiasco, the study finds (New York Times, 8/15). The researchers said the risk of cardiac problems was "acceptable" because the heart harmed could be put back together in the majority of women. Evesta write, "If the cardiac squad effects of Herceptin treatment can be manage, the drug is past the worst to use," adding that women with advanced breast cancer should undergo an consideration of their cardiac health formerly using Herceptin and during its use (BBC News, 8/14). The study author slant off that the heart problems associated with Herceptin's use "might be a symbol of a primary kindness for patients with early stage breast cancer" (San Jose Mercury News, 8/15). The study did not put alongside each other women with early stage breast cancer taking Herceptin, according to BBC News (BBC News, 8/14).
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