Researchers Identify New Genetic Marker For Breast Cancer

An entire shipment of investigators lead near scientists at
Memorial Sloan-Kettering Cancer Center (MSKCC) and the National
Cancer Institute flood up identified a untried genetic sign of
stake in favour of breast cancer.
Women together with this DNA changeability be at a 1.4 times
greater risk of surfacing breast cancer compare to
those pithy the variation. The findings are to be published
online by the tenderloin of March 3, 2008 surrounded by the
monthly Proceedings of the National Academy of Sciences.

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These alterations may materialize more a set in individuals who
have convinced generous of germ than in manager without such
disease. In this study, a new gene locus, a specific slot on a
chromosome where on earth a gene be situated, be associated with
breast
cancer risk. That gene locus is on the extended arm of
chromosome 6.

"These research findings are of excessive murmur because of the
stripe of genome- wide unembellished association used to hit upon
this new locus and also by means of others in recent months,"
said Bert Gold, PhD, a Staff Scientist at the National Cancer
Institute in Frederick, MD., and initial author of the relevant
study.

While the risk associated with this genetic marker is a great
deal demean than that of BRCA genetic mutation for archetype,
this bringing to fluffy will accessory the supportive of the
genetic variant that necessitate yourself to breast cancer.

Researchers used sample largely from MSKCC, but also from other
encampment in the US, Canada, and Israel. Participants be all of
Ashkenazi (Eastern European Jewish) ancestry. The study used a
three-phase logo centered on 249 family with multiple cases of
breast cancer
and no mutations of the BRCA genes.

"This just now identified genetic marker will not have any on the
spot clinical implication or impact on current screening
guidelines for familial breast cancer," said Dr. Offit. "As such,
a trialling for these marker is not untaken to the undisputed
population and these test should be accomplish singular as level
of research study." Dr. Offit's research team is in a minute
corroborate that this risk marker is observed in other
populations, and is study possible change in two genes in the
chromosome 6q county.

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