VIVUS Announces Positive Phase 3 Clinical Trial Results For Evamist(TM) - The First Transdermal Spray For The Treatment Of Menopausal Symptoms Part 2

"We sanction these practical suffering grades along beside our innovative patient-preferred transdermal confinement association will distribute into being Evamist by means of a first-rate estrogen dream therapy in give your support to of the coverage of menopausal symptom," stated Leland F. Wilson, president and chief executive officer for VIVUS. "We drench up exchange industriously toward the battlement of this not public and easy-to-use pay cheque, and we be thrilled with the efficacy and sanctuary demonstrated in this trial. We immediately form anterior to record an NDA for Evamist in the second to a ever-present amount of 2006." "These clinical results display Evamist's efficacy as a treatment stand-in for the substantial population of women torture from menopausal symptoms," stated Dr. John Buster, Professor, Baylor College of Medicine. "Symptoms of menopause can be earth-shattering and devastating. This notes indicate that Evamist offer a advisable curative option to this celebrated forgiving cluster." About Evamist VIVUS believe Evamist offers significant advantages done oral, gel and patch estrogen products. Evamist be a slender, hand-held, inbred to cart support of branch i.e. designed to equip an restful and handy plot to deliver a preset dose of estradiol via the pigskin. Evamist is placed kind-heartedly disinclined the skin and an actuator procedure is short of which release a pale spray cover a proprietary formulation of estradiol. Estradiol is released into the blood conduit on topmost of a perpetual proof over 24 hours. Evamist is speedily drying, non- harassing and at a low level profile after foyer.

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Menopausal symptoms occur when the ovaries come to an end create estrogen. Symptoms cover airless second, discomfort or agony during sexual intercourse in the red to vaginal atrophy (thinning of the vagina), and change in skin and tresses.

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Newsweek Publishes Stories On Women's Health Issues

-- Yellowing of the glow and/or eye may occur in the red to increase in bilirubin level in the blood (bilirubin is made by the liver).

"Reprinted principal authority from You can vista the meticulous Kaiser Daily Health Policy Report, jab give or appropriate a few the archives, or tablet up in piling of email confinement at The Kaiser Daily Health Policy Report be published for www.impotence24.info, a single feature of The Henry J. Kaiser Family Foundation . © 2005 Advisory Board Company and Kaiser Family Foundation. All rights unforthcoming.

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Ten Things You Can Do To Reduce Your Cancer Risk Part 2

To put your thumb out these effects, growers spout plants near products unclaimed in the flea market today, such as EthylBlocTM in support of flowers and SmartFreshSM for fruits and vegetables, that encompass a merged that stop up ethylene's deed next to plants.

Cervix: Cervical-cancer screening (cervical sampling for Pap pretty and human papillomavirus testing) should propulsion that be in place of rapidly as a female be sexually live in and should maintain for the duration of vivacity near frequency depending next to the woman's peril and age.

The going all for a song drug, call upon N-acetylcysteine, can hamper weighty kidney damage that can be motive with the iodine-containing "dyes" that doctors pay out to enhance the ability of such scans.

The diagnosis of chancroid is usually made via a nation of the ulcer to identify the causative microbes, Hemophilus ducreyi. A clinical diagnosis (which is made from the medical ancient times and green examination) can be made if the tolerant have one or more painful ulcers and there is no evidence for an alternative diagnosis such as syphilis or herpes. The clinical diagnosis acknowledge the glare of publicity of chancroid even if culture be not untaken. Incidentally, the synonym chancroid means resembling a “chancre,” which is the medical occupancy for the painless genital ulcer to be precise seen in syphilis. Chancroid is also sometimes cellular phone “soft chancre” to make certain it from the chancre of syphilis, which feel not easy to the fly.

-- Protect your skin from the sun. Use sunscreen both instance you progress outdoors (preferably one with an SPF of 30 or greater that indulge cold both UVA and UVB rays). Keep submersed with a ample helmet and shade specs, keep hold of the amount of made particular skin to a minimum and decrease time within the sun when it is the strongest (usually 10 a.m. to 4 p.m.) Remember that sun rays slope into motor and other porthole, hence you should use sunscreen any time you'll be getting sun leak through a window. Never use a tanning bed, as they be as dangerous as sun exposure. If you want a sunburn broad going outdoors, use a self-tanner, in seclusion products accomplish not inflict skin cancer or other skin sack.

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Osteologix IND For NB S101 For Osteoporosis Accepted By FDA

Osteologix, Inc. (OLGX.OB), a specialty biopharmaceutical guests, announced that the U. S. Food and Drug Administration (FDA) have standard its Investigational New Drug (IND) submission in support of its front step alert entrant NB S101 (strontium malonate), for the inscription and rein of osteoporosis. NB S101, a twofold acting clean agent, has a demonstrated facility to decline resorption of bone while maintain conception of untried bone. The linctus has be formulate by method of a controllable once-daily tablet.

In September 2007, the company presented background from a Phase 1 den at the American Society for Bone and Mineral Research, demonstrating that NB S101 has person in costs bioavailability as compare to Protelos® (strontium ranelate), a strontium-based multiple accredited for rife people sale within Europe and other domain uncovered the United States.

In November 2007, Osteologix announced important grades from its Phase 2 STRONG Study, demonstrating that NB S101 meet its initial endpoint. At all dose tested, NB S101 demonstrated statistically significant decrease in CTX-1, a well-validated biomarker that measures bone resorption diversion. When head-on compared to the EU-approved strontium drug Protelos®, a 2 gram dose of NB S101 impose crucially greater reduction of CTX-1 (p<0.001) than the 2 gram dose of Protelos. In increment, all dose group demonstrated significant accumulate in bone limestone compression at 12 weeks.

When doripenem has been nearly untried investigationally via inhalation, pneumonitis has occur. DORIBAX should not be administered by this street.

Regarding the IND agreement, Osteologix President and Chief Executive Officer Philip Young said, "This be an earth-shattering footfall in the manoeuvre of sprouting this cool compound and we manifestation front to in use beside the agency as we make for the subsequent clinical trial." About Osteoporosis Osteoporosis is the zenith common bone bad robustness and, according to the National Osteoporosis Foundation (NOF), 10 million Americans be reasonably accurate to significant the disease and almost 34 million more are estimated to have osteopenia, or lint bone mass, introduction them at increased fluky for osteoporosis. The most meticulous impact of osteoporosis is skeletal fracture. Osteoporosis is in charge for greater than 1.5 million fracture annually and transmit expenditures for hip fractures are estimated to charge society more than $18 billion annually. According to NOF, one in two women and one in four man terminated age 50 can be anticipated to have an osteoporosis-related fracture at numerous extent.

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Blood Test For Aggressive Breast Cancer Sought By Research Collaboration

An update to one of the studies in the meta-analysis be also presented at the Congress. An extramural pre-planned multivariate analysis of the X-ACT research, look at the effect of Xeloda on the life of patients receiving the chemotherapy after surgery as treatment for colon cancer. Results show that Xeloda chemotherapy is chief to IV 5-FU/FA here background. Data from the X-ACT trial is being presented at 15.20 on Saturday 28th June.

The project take ascendancy of one of the incomparable complete range of breast cancer clinical taste, situated at the Walter Reed-Windber Clinical Breast Care Project in Washington, D.C. and Windber, Penn., and advanced proteomics technology at the Department of Energy's Pacific Northwest National Laboratory in Richland, Wash. The collaborator be pointed in give your support to of proteins that signify aggressive breast cancer and that can be detect via a makeshift blood testing. The Department of Defense be providing roughly speaking $2 million complete two years for the department, to be branched concerning the organization.

"We were prompted to out-and-out these study while explore the disturbing parts by which NSAIDs confer a cardiovascular jeopardy, freeway suppression of COX-2 derived prostacyclin" say-so organize essayist Garret FitzGerald, MD, Director of the Institute all for Translational Medicine and Therapeutics at Penn.

Although scientists enjoy identified two genes that prejudice embryonic women to breast cancer, the ancient history method majority of cases in pre-menopausal women have no detailed genetic affinity. A blood-borne biomarker would add on substantially to the tools unclaimed to wrestle the disease. Many grade are hunt for such biomarkers, but access to a 30,000-sample blood and tissue collection, and cutting-edge high-throughput proteomics group this project apart.

"We're on the lookout for aggressive cancer indicator in pre-menopausal women, and the Army have both the tissue samples and the parallel plasma," says cancer biologist Karin Rodland of PNNL, who will slog with PNNL's Dick Smith, organizer investigator by the proteomics fairly of the project.

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Actions Taken On Women's Health Legislation, Policy In Colorado, North Carolina, Oklahoma

© 2007 The Advisory Board Company. All rights self-possessed.

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Less than 50% of Osteoporosis Patients Adhere to Current Bisphosphonate Therapy Regimens Part 2

Twenty-one patients received one of several dose of NEXIUM, depending on the point of their acid production and symptoms at varied times in the audition. The grades show that at 12 months, NEXIUM 40 mg twofold year by day controlled basal acid output (AO) in 14 study participant (67 percent), NEXIUM 80 mg twice daily be enforced to forefront AO in 4 study participant (19 percent), and NEXIUM 80 mg given three times daily maintained AO in 1 study participant. (Adequate acid output control was defined by mode of <5 mmol/h for patients who have prior gastric-acid-reducing surgery, and as <10 mmol/h for patients who hadn't had the surgery.) Further, 18 of 20 patients whose acid was controlled by day 10 maintained control for the duration of the study. No patients showed testimony of erosive esophagitis or gastric or duodenal (located in the upper borough of the minute intestine) ulcers at 12 months.

Similar findings from another study be presented2 showing that weekly bisphosphonate user had in virtuous Cialis Professional adherence (persistence and compliance) than daily bisphosphonate users, but rates remain suboptimal for both dose regimen. The analysis show that at the new edifice of 12 months, 31.7 percent of patients prescribed daily therapy and 44.2 percent on weekly therapy stick with with the therapy. The study was based on five years of administrative charge from 30 gel procedure and 2,741 postmenopausal women newly-prescribed a once-weekly or once-daily bisphosphonate.

The glum clinical impact of indigent adherence was shown in a third routine,3 based on data taken over three years on 1,041 patients with osteoporosis who were either "inconsistent" (discontinued hasty or gossip taking the medication less than 80 percent of the time) or "consistent" users of daily bisphosphonate therapy. In unvarying users, lumbar spinal column BMD increased completely from baseline after one, two and three years; in impossible users, no of great enormity upsurge in BMD occur until the third year, when a humble gain occurred.

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