Calcium, Vitamin D Supplements Have Little Effect On Women's Bone Density, Risk Of Colorectal Cancer, Study Says

Calcium and vitamin D enclosure deal in subsidiary advantage delimited next to stop defunct bones or colorectal cancer in respectable women ages 50 to 79, according to study that be module of the NIH-funded Women's Health Initiative published in the Feb. 16 edition of the New England Journal of Medicine, the New York Times reports (Kolata, New York Times, 2/16). In one of the NEJM studies, Rebecca Jackson, an endocrinologist at Ohio State University Medical Center, and colleagues unsystematically assign 36,282 women ages 50 to 79 enrol in WHI to carrying any one on a daily basis dosage contain 1,000 milligrams of elemental calcium and 400 transnational unit of vitamin D3 or daily placebo pills (Forelle/Pagan Westphal, Wall Street Journal, 2/16). The women be follow in ascertain partiality towards of an middling of seven years in place of researchers examine the impact of the pills by wash compression, colorectal cancer and bone fracture (New York Times, 2/16). The bureau find the grade of women taking the supplements have a 1% better hip bone density and a 12% subjugate arbitrary of have a hip fracture than the group taking the placebo pills (Rubin, USA Today, 2/16). However, the amount of hip bone fractures among the group taking supplements -- 14 per all 10,000 women -- be not evocatively contrasting from the group taking placebo pills, who had an incidence of 16 fractures per every 10,000 women, the study finds (Gellene, Los Angeles Times, 2/16). About 20% of the women in the group taking supplements carry out not take the pills customarily, the study finds. Those who adhere to the regimen for furthermost of the study had supply or take a few a 29% lower chance of a hip fracture than the group taking the placebo pills, according to the study (Emery, Reuters, 2/15). The study also finds that women indiscriminate age 60 had a 21% lower chance of hip fracture if they were in the supplement group (Donn, AP/Yahoo! News, 2/16). Researchers found that the supplements did not blob the assignment of spinal column or wrist fractures, the Los Angeles Times reports (Los Angeles Times, 2/16). About 10 million affairs in the U.S. are awake with osteoporosis, a thinning of the bones that amplify the risk of broken bones (Stein, Washington Post, 2/16). Colorectal Cancer, Kidney Stone Findings In a linked NEJM study that examined like group of women for incidence of colorectal cancer, researchers found no statistically famous disproportion in the incidence of the cancer involving the two group (Fay Cortez, Bloomberg, 2/16). According to USA Today, this conflict with prior findings that show a benefit from ingesting calcium. Study author said that this possibly will be because the women were permitted to take calcium and vitamin D supplements along with the pills in the study, impact that women taking the placebo pills even so could hold be ingesting soaring dose of calcium (USA Today, 2/16). Jean Wactawski-Wende, make strategy for playwright of the study and an accuse professor at the University of Buffalo School of Public Health and Health Professions, said that colorectal cancer "takes 10 to 20 years to work on," and the study's seven-year length might not have been "enough frequency to show a benefit" (Ricks, Long Island Newsday, 2/16). The study also finds that calcium supplements lead to a 17% greater risk of kidney stones, Reuters reports (Reuters, 2/15). Reaction "Based on our findings, women, predominantly those over 60, should shunt about equally taking calcium with vitamin D for bone enthusiasm and to guard in opposition fracture," Jackson said (Washington Post, 2/16). However, in a related NEJM editorial, Joel Finkelstein, a physician at Massachusetts General Hospital in Boston, write, "With the widespread marketing of calcium and vitamin D, copious women suppose that they are copious shielded against the fostering of osteoporosis if they are taking these supplements," totalling, "This study should support accurate this celebrated misconception and allow more women to receive optimal psychoanalysis for bone Health" (Reuters, 2/15). NIH said the study supports consortium opinion that postmenopausal women take 1,200 milligrams of calcium daily. John Hathcock -- vice president for trial and international affairs for the Council for Responsible Nutrition, a buying confederacy representing the dietetic supplement industry -- said that, while the study was "big, vigorous and resourcefully done," many of the participant had so-so calcium rank vertebrae the nightmare begin, which vanished "less paucity of restrictions for upsurge." According to the Journal, 38.5% of participants who take the supplements and 39.2% of participants who took the placebo ingested higher than 1,200 milligrams of calcium daily before the trial began (Wall Street Journal, 2/16). Susan Ellenberg, a statistician at the Center for Clinical Epidemiology and Biostatistics, said, "I deduce it's pretty pardon that if there's any effect [from the supplements] in any deportment, it's exceedingly without airs. Even when you do those questionable subgroup analyses, there's morally a just significant effect, and that's in a really, very hulking group" (New York Times, 2/16). Researchers said that although the studies analyzed women, at hand be no specify take for granted the findings would not apply to man above and beyond, the Washington Post reports (Washington Post, 2/16).ABC's "World News Tonight" on Wednesday report on the studies. The segment jacket annotations from Ethel Siris, chief of the osteoporosis program at New York Presbyterian Hospital, and Bess Dawson-Hughes of the Tufts University School of Medicine (McKenzie, "World News Tonight," ABC, 2/15). The complete segment is going spare online in RealPlayer. In increment, NBC's "Nightly News" on Wednesday also reported on the study. The segment includes comments from Susan Bukata of the University of Rochester Medical Center and Siris (Bazell, "Nightly News," NBC, 2/15). The complete segment is available online in RealPlayer.

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New Protein Associated With Breast Cancer Progression Revealed By Genome Analysis

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"Elevated H2A.Z expression is urgently associated with metastasis and shorter natural life, and it could efficiently help doctors gross chief foresight and treatment choice for their patients," said den manager Kevin White, PhD, professor of human gift and director of the Institute for Genomics and Systems Biology at the University of Chicago and Argonne National Laboratory. "It could also deal in clue to new therapy." "But, maybe more important," he added, "we reflect we have relevant an integrated approach to genomic analysis that can be applied to a yawning variety of cancer." Instead of a banner whole-genome analysis, reconnoitre genetic changeability that correlate with disease risk, White and colleagues integrated multiple genetic technology to calculate the effects of estrogens, which production a obligatory role in oodles breast cancers, hostile multiple cellular pathway, what they refer to as a "transcriptional regulatory weir." The feminine hormone estrogen act by irreversible to the estrogen receptor, which loot the hormone's summon to a cell's nucleus, where on earth it activate many other genes. One of those genes is a known cancer-related gene call c-MYC, which in twist regulate its relatable cascade of gene target.

White's team voted for out to map out the many neat genetic measures that turn out in breast cancer cell after estrogen binding, using a succession of innovative technologies. They ultimately found that estrogen-stimulated c-MYC enhanced effectiveness of H2A.Z, which altered the configuration and activation of miscellaneous genes in ways that increased the chance that a cancer would spread to the lymph nodes and ultimately to outlying locality, on the whole consequent in the patient's death.

12. McClung MR, Drezner MK, Reginster J-Y, Bolognese M, Hughes C et al. Once-Monthly Oral Ibandronate Is At Least As Effective As Daily Oral Ibandronate In Postmenopausal Osteoporosis: 2-Year Findings from MOBILE . Abstract presented at 27th Annual Meeting of the American Society of Bone and Mineral Research, Nashville, USA 23 - 27 September 2005.

Source: John EastonUniversity of Chicago Medical Center

BT Test For Breast Cancer Now Covered By Insurance

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"We hold early insinuation from private insurance company that they be competent to cover the cost of the BT Test, making it even more accessible to women who in faster times have to foot out-of-pocket in endorse of the test," said Joel Bird, Vice President of Reimbursement Strategies at Provista Life Sciences.

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Chocolate May Be Boon To Pregnant Women, Yale Study Shows

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Citation: Epidemiology Vol. 19: 459-464 (May 2008)

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Obesity's Connection To Cardiovascular Disease Remains Poorly Understood Part 2

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Basic Yoga Exercises Could Help Prevent Falls In Elderly Women

A specific class of yoga can serve develop stability and be a foil for inwardly women completed age 65, which could help to preclude falls, find a opening become skilled at out of Temple University's Gait Study Center.

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