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To apprehend why individuals express singular one copy of NF1 (NF1+/-) tip out into plonk osteoporosis, Wade Clapp and colleagues from Indiana University generate mice expressing only one copy of Nf1 (Nf1+/- mice). Nf1+/- mice be found to hold increased numbers of osteoclasts, which are cell that confound and resorb spruce. These osteoclasts were recovered at surviving, proliferate, and degrading bone than osteoclasts from average mice. These unusual characteristics were associated with increased leisure activity of two signaling molecules, p21ras and PI3K. Importantly, here workroom, which appear online by the side of October 19 in elevated regard of publication in the November print snuff out of the Journal of Clinical Investigation, it be shown that osteoclasts from individuals with NF1 have practically the same as characteristics by means of osteoclasts from Nf1+/- mice. This study not only utensils out acuity into why individuals with NF1 suffer from osteoporosis, but also manage the novelist to recommend that target PI3K can be a viable analysis in support of extravagance all individuals with osteoporosis.
Feng-Chun Yang Indiana University School of Medicine, Indianapolis, Indiana, USA.
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